4. Kidneys and Autoimmune Disease
نویسنده
چکیده
The human immune system limits invasion of foreign organisms and eliminates foreign cells. Discrimination between self and foreign structures is essential in this process. Ability to recognize ‘‘self’’ and limit ‘‘auto’’-immune responses against selfantigens is defined as tolerance. In many situations, the mechanisms either inducing or maintaining tolerance are disrupted. This breakdown leads to activation of autoreactive cells which, in turn, may initiate overt autoimmune disease.
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